Posted on:April 29, 2026

ML Systems Engineer at Periodic Labs

Periodic Labs is hiring a ML Systems Engineer in Menlo Park, CA, US. On-site. Pay: USD 250k-350k/yr.

About Periodic Labs

Periodic Labs is building AI scientists and autonomous laboratories to accelerate scientific research, with a focus on materials, energy, and related physical sciences. The company aims to create AI systems that can form hypotheses, run experiments, and learn from the results, generating new knowledge through interaction with the physical world.

ML Systems Engineer job description

About Periodic Labs

We're an AI and physical sciences company building state-of-the-art models to accelerate breakthroughs across materials, energy, and beyond. Backed by world-class investors and growing rapidly, we operate at the pace the frontier requires. Our team brings deep expertise, genuine ownership, and an insatiable drive to push the boundaries of what's scientifically possible.

About the Role

You’ll work alongside some of the world’s leading ML systems engineers, including leaders behind Megatron-LM, SGLang, Liger Kernel, TorchRec, CleanRL, TorchRL, and JAX-MD.

We’re looking for exceptional ML Systems Engineers to build the agentic infrastructure powering our large-scale training, inference, and reinforcement learning. You’ll own critical pieces of the ML systems stack to maximize performance, scalability, reliability, and productivity for both engineers and AI agents.

What You'll Do

  • Build and optimize large-scale training and reinforcement learning infrastructure while ensuring its correctness

  • Develop high-performance inference and serving systems

  • Design distributed runtimes and scheduling systems for complex ML workloads

  • Build secure and large-scale sandboxing and execution environments

  • Optimize memory, GPU kernels and communication for maximum throughput and end-to-end efficiency

  • Improve scalability, reliability, and efficiency across the ML systems stack

What We're Looking For

  • Strong systems programming and performance engineering skills

  • Experience building high-performance ML infrastructure at scale

  • Ability to own complex technical problems end-to-end

  • Strong coding ability and engineering judgment, including the ability to work effectively with AI agents to design, implement, test, and debug complex systems

  • High ownership, fast execution, and a passion for pushing the frontier of AI systems and accelerating scientific discovery


You should have deep expertise in at least one of the following:

  • Training: Strong experience building, debugging and optimizing large-scale training systems with Megatron-LM. Familiarity with TorchTitan, FSDP, veRL, Slime, or other distributed training systems is a plus.

  • Distributed Runtime: Strong experience with Ray. Familiarity with Monarch or other distributed execution frameworks is a plus.

  • Inference: Strong experience with SGLang. Familiarity with vLLM, TensorRT-LLM, or production LLM serving systems is a plus.

  • Sandboxing: Strong experience with secure execution environments, containers, virtualization, or code sandboxing.

  • GPU Kernels: Strong experience with CUDA, Triton, CUTLASS, CuTe, or custom GPU kernel development.

  • GPU Communication: Strong experience with NCCL, NVLink, InfiniBand, RDMA, GPUDirect RDMA, or large-scale communication optimization.

Mechanics

Minimum education: Bachelor’s degree or similar experience

Location: Menlo Park, CA (Soon: San Francisco, too)

Compensation: $250,000-$350,000 base + equity

Visa sponsorship: Yes, we sponsor visas.

We’re building a team of the world’s best — the scientists, engineers, and problem-solvers who don’t just follow the frontier, they define it. If you’re driven to bring AI to life in the physical world and make discoveries that have never been made before, you belong here.

Apply now

Applications go straight to Periodic Labs. We never sit between you and the employer.

Apply now ↗
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